I completed the game with out ever playing a stage more than 3 times.
Just kidding. Really, the only rage I had were on long levels. You could get past the hard part and back, then make a stupid mistake and throw your mouse across the room. So, most of the Rapture levels and The End levels.
Why were you using your mouse? Afaik it's keyboard controls only
On Topic: Most rage-filled moment would have to have been Dr. Fetus Boss fight. Getting right to the end and then running backwards straight into his missile for no reason.