I'm having pretty much the same problems as everyone else; I can't change to fullscreen, change the resolution, quit, or enter a warp zone. On top of that, the screen doesn't ever scroll up during the CHAD level in the hospital world. Hope it gets fixed soon, because thus far I'm loving the game.

EDIT: It appears, as quip said, that the level does indeed go up, but only when I return to where the key was.