Hmm, good points. 2 questions:
1) These unlocks, do you keep them across the different games?
2) Do you see everything the game has to offer in 1 game run? Or do you have to play multiple games to play against/with all different bosses, enemies, items,...?
Thanks
1) No
2) I've died 7 times, beat the game once, and I'm still finding new stuff I hadn't seen before. Besides, you unlock new stuff by playing more, like new bosses (I beat the game and a new Boss that couldn't appear before showed up on the basement). There's about 100 items, 50 different enemies, randomly generated rooms, 14 bosses, multiple endings, unlockable playable characters, and there's a HELL of a lot more.
So if you spend 5 bucks, don't worry, you'll have WAY more than what you paid for.
Also, Edmund said if many people buy the game there'll be free DLC!
So make yourself a favour.
And buy it please.
It's 50 cents cheaper till the 5th of October.
And your money's on good hands. I think.
Definitely. Buy it.
ALSO: For those of you wondering how my Isaac look when I beat the game, he looked like this:

You can't notice in the pic because of the position Isaac is in, but he had a red pentagram on his forehead and shot blood instead of tears.
Making pacts with the devil in this game is awesome. Before turning him into a satanic maniac, though, he was kind of transvistite-ish... He had lipstick and high heels, lol.
I'm loving this game so far :)
Oh, and, yeah, it does say Explosive Diarrhea up there. It makes you crap bombs for a short period of time. Fun, especially when they don't tell you what it does.