Just had the most intense game of Isaac ever. It was a run with Eve and a few challenge rules (no Brimstone/Mom's Knife, no spending money, complete every room on every floor minus challenge rooms). The game started trolling me right from the get-go, giving me the Poop and a beggar on Basement 1, as well as loading me up with coins. On one floor I wasted 3 or 4 bombs looking for the secret room, finally found it, and got a slot machine. Blew that up, and got a ??? pill that of course had to be Health Down.
Basically what I got was Lard, The Pact, Wire Hanger, Robo Baby, L2 Meat Boy, Halo of Flies, Bob's Rotten Head and Chocolate Milk. I had some soul hearts that lasted me till about Womb 2. From then on, I had to run around with a measly 3 hearts and nothing to give me more. I got some of the tougher Womb 2 rooms (dual Sloth, dual Envy) and not much of a break on hearts, so I just had to not get hit. Thankfully Scolex gave me a health up, but even then it's me vs all of Sheol with 4 hearts.
That floor made me the most nervous I've ever been in this game. Lots of headless horseman rooms, 2 rooms with 6 knights apiece and only a couple of bombs (but I made sure those bombs did some damage), 2 rooms with The Fallen (thank god for Bob's Rotten Head), and I had to face dual Greed 3 times. Halo of Flies and Meat Boy really saved my ass in those rooms. The one break I got was that I only got one room with eye lasers in it.
Somehow, I got to Satan with my 4 hearts intact. At this point my nerves are through the roof because I can only get hit 3 times by this boss. Bob's Rotten Head took care of the Fallen, and Satan 1 is as predictable as ever. Satan 2 though, took a while to kill because Eve wasn't strong. I had to dodge stomps and bomb leeches for a while, and it was very intense. I ended up only getting hit once.
As you can see, I was so nervous I forgot to use The Devil card which I had reserved for Satan.
Phew, that certainly was a game, one I thought I had no chance in hell of winning.