Edmund does all of the art in Flash. For Super Meat Boy they converted it to some format using a tool that Tommy made. I'm pretty sure SMB was coded in C++, but The Binding of Isaac is 100% made in Flash.
Neither member of Team Meat has attended a college, but it doesn't hurt to go yourself if you can afford it, provided you find a decent tech school around with a game development program.
There's plenty of tutorials floating around to get you started with just about everything though. Anything they don't teach you you can teach yourself through practice and experimentation.
Here's some tool recommendations:Programming:
- Microsoft Visual Studio (or Visual Studio Express)
- Notepad++ (Not an IDE, but you should use it regardless)
- 3DSMax (Industry standard, but expensive)
- Blender (High learning curve, but free and robust)
- Photoshop (If you can afford it)
- GIMP or Paint.NET (I prefer Paint.NET)
If you don't think programming is right for you, give Flash (Actionscript 2.0) a try, or start making Lua scripts for Garrysmod. You could also try mapping for Source or the Unreal Engine. I can't give any advice on Game Maker having never used it, so maybe GameRoom will pop by the thread with some advice.
Hopefully you'll find an aspect of game development that suits you. If you don't, ideas alone aren't going to get you anywhere. GOOD LUCK!